Cause of Cushing’s syndrome
Increasing the glucocorticoid hormone secretion of cortisol leads to Cushing’s syndrome, which is a metabolic disorder and affects the metabolism of carbohydrates, proteins and lipids.
Cushing’s syndrome is known as obesity, hypertension and high cortisol levels.
There is an increased physiological correlation of cortisol in the last trimester of pregnancy and those who are doing heavy exercise.
Pathologic conditions Cortisol enhancement includes exogenous cushing syndrome (endogenous) or endogenous (endogenous) syndrome and several psychiatric conditions including depression, anorexia nervosa, panic disorder, and alcohol deprivation.
In most cases, the cause of endogenous cushing syndrome is hyperplasia (increased cell proliferation) of the adrenal gland (super kidney), which occurs due to increased secretion of the ACTH (adrenocorticotropin) hormone from the pituitary gland and the non-acute production of ACTH by a non-pituitary source To give
The incidence of pituitary-adrenal adrenal hyperplasia is three times higher in women than in men, and the most commonly occurring age is the third and fourth decades of life.
The most common cause of exogenous Cushing’s syndrome is the administration of steroids.
Long-term administration of ACTH, hydrocortisone or its analogues results in similar clinical symptoms of the disorder that is known as Cushingoid syndrome. Cushingoid syndrome is most commonly associated with oral or injectable corticosteroid medications. In this syndrome, long-term consumption of corticosteroids increases the body’s body fat, which is due to an increase in energy intake and a decrease in metabolic rate.
Considering this point in considering the cause of obesity, patients should be aware of the history of their medications.
Symptoms of Cushing’s syndrome
Weight Gain Something else Fat accumulation,
especially in the middle part of the body, the face (causing a rounded face), between the shoulders and the back There are signs and purple spots on the chest, arm,
abdomen and thigh Lightening the skin that easily bruises. Skin damages that slowly improve.
– Okay Tired Muscle weakness
– It does not tolerate glucose
– Increase thirst
– Increase urine Bone loss (osteoporosis) High blood pressure Crack
– Cognitive and functional disadvantages
– Anxiety Beat up Depression Increase the incidence of infections
– People may notice excessive hair growth in the face and body, as well as chest disorder or menstruation.
Men may suffer from:
– Erectile dysfunction
– Losing libido
– Reduced fertility
Children with this disease are usually obese and have a faster growth.
If you have Cushing’s syndrome but do not treat it, Cushing’s syndrome can lead to:
– Bone loss
– Bone defeat
– Losing muscle and weakness
– High blood pressure
– Type2 diabetes Infection
– Great pituitary tumor
– Kidney stomach
Cushing’s syndrome due to pituitary tumors can disrupt the production of other hormones.
When should you go to a doctor?
If you are taking a corticosteroid medicine for a particular illness and have symptoms similar to those of the Cushing’s syndrome, you should go to the doctor to check it out.
Even if you do not use corticosteroid medications, but have symptoms similar to those of the syndrome, go to your doctor.
Preventing Cushing’s syndrome
If you use corticosteroid inhaled medicines, wash your mouth after breathing.
If you notice an abnormal swelling in the face or neck,
high growth of facial hair in women and severe sexual dysfunction, see a doctor immediately. Use low energy.
High blood pressure, which is one of the symptoms of this syndrome, requires reduced salt intake. Visit the gastroenterologist. This specialist tests blood cortisol levels. Follow the eye doctor repeatedly.
Cataracts are one of the symptoms of Cushing’s syndrome.
Anxiety or stress