Treat viral diseases by chemical drugs
At first sight, it was thought that attempting to treat viral diseases by chemical drugs was ineffective because the virus only multiplied inside the cells with the cooperation of the cells, and any factor that would stop the proliferation process could cause the host cell to be alive Thus, in the four stages of the cycle of virus replication, processes depend on which cells do not necessarily need them.
1. Initial attachment of the virus to the cell, which occurs at specific points of the cell surface
2. The rRNA (Transcription) transcription of viral nucleic acid that requires a specific virus polyserase
3. Translates viral mRNA into a viral protein that is transmitted by the protein source (TIP: Translation_Inhibitory_Protein) It stops. This is a matter of difference. Interferon, a kind of cellular protein with a molecular weight of about 19,000 daltons, including alpha, beta and gamma interferon alpha, is produced by the alien nucleic acid.
Interferon interrupts the synthesis of a large variety of viruses. Replacing the viral nucleic acid that needs viral enzymes does not in any way affect the cells. RNA viruses may be particularly susceptible to stopping the synthesis of such enzymes
Selective drugs that affect each of these stages are known to be effective in laboratory experiments, but clinically relevant for the treatment of amantadine, acyclovir, and rodabine and thymus carbazone (Isatin_B_thiosemicarbazone) And oxyuridine iodide (Iodkdeoxyuridine) It is worth noting here that in most viral diseases, virus replication is almost complete before symptoms appear, and, moreover, laboratory diagnosis often takes several days or longer. Another problem is the emergence of the virus Mutants are resistant to these drugs and their occurrence is as large as bacteria.
The virus binding to the host cell membrane stops cell culture and laboratory animals by the bacterial enzyme called neuraminidase. This enzyme destroys cell receptors for migraineurs and some paramyxo-viruses. The symmetrical triangular amine Adamantanamine prevents the swallow of the A2 virus. None of these drugs are currently used in the treatment of human diseases.
Rifampicin is an antimicrobial agent that interrupts transcriptional DNA by binding to DNA-linked Polarase RNA and prevents replication of the smallpox virus in cell culture. The way this substance works in viruses is not known and has not been used against human smallpox.
The translation of viral mRNA into a viral protein by TIP, which is created in response to interferon, is stopped. The therapeutic utility of interferon is not very practical at the moment, because much of it is needed. Another method is to stimulate the host cell to produce it by administering a bipolar poly-nucleotide, such as poly-inosinic acid, cytodilic [Polyinosinic: Cytide (Polyc: 1)] They do.
This method has been effective against several types of viruses in cell cultures and in animals, but limited in human use (herpes and lips infection) because:
1: C has a toxic effect when injected into the body. Methyl Otenephrine-beta-thiosuminesis Carbazone (Marburan) is successfully used in the treatment of smallpox. The drug has reduced the risk of attack in some epidemics in India from 75% to _95%. The defect in this medicine may cause vomiting in some cases.
2: The replication of the nucleic acid in the cells of the infected cocto virus stopping the viruses with guanidine or benzimidazoles stopped. These drugs seem to stop the synthesis of the viral polarized RNA. The drugs are not effective in animals because the probability Prolonged drug mutations are rapidly emerging. Iodo-ureidine when used topically in the early diagnosis of herpes simplex infection. This drug, instead of thymidine, is introduced into a newly created viral DNA and produces a barren molecule.
Chemotherapy against viruses is in the early stages, and the materials that have been referred to about the virus cycle show that drugs can be discovered in the future against viruses. Treatments for viral illnesses of the respiratory system and infectious, slow, and carcinogenic viral infections are absolutely essential. Today, one of the ways to combat acquired immunodeficiency disease (AIDS) is chemical treatment, and there is a lot of research to find the right drugs. Drugs such as zidovudine are used to treat the AIDS virus.